The Science Behind Type 2 Diabetes
A means to enhance intact incretins
After release, GLP-1 (7-36) and GIP (1-42) are rapidly metabolized by the enzyme DPP-4,which is located in various tissues, on the capillary surfaces, and in soluble form in the circulation.
DPP-4 cleaves off the first 2 amino acids from the intact peptides, producing 2 truncated peptides, GLP-1 (9-36) and GIP (3-42),which are mainly eliminated through the kidneys.
These truncated peptides do not activate the respective GLP-1 or GIP receptors in the pancreatic alpha and beta cellsand do not affect insulin release or glucose control.
DPP-4 inhibition has been shown to slow the degradation of GLP-1 and GIP to their truncated forms, therefore prolonging the survival of intact GLP-1 and GIP and their effects on glucose regulation.
Important Information About JANUMET and JANUVIA
JANUMET is indicated, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.
JANUVIA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
JANUMET / JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
JANUMET / JANUVIA have not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk of developing pancreatitis while taking JANUMET / JANUVIA.
Before prescribing JANUMET, please read the Prescribing Information, including the Boxed Warning about lactic acidosis. The Medication Guide also is available.