Dynamics of the disease
Learn more about the normal, complex process of glucose homeostasis and the mechanisms that lead to type 2 diabetes, including the role of incretins in this process.
Understanding Incretins
Incretins play an active role in mediating pancreatic beta- and alpha-cell responses in healthy individuals. However, this effect is diminished in type 2 diabetes.
Insulin Secretion
The coordinated functioning of pancreatic beta and alpha cells is essential to normal glycemic control.
Insulin Secretion Abnormalities
Although insulin resistance is found in almost all patients with type 2 diabetes, the defect in insulin secretion accounts for the development of hyperglycemia and progression of the disease. 12
Evolution of Incretin Science
The area of diabetes research is rapidly evolving. In recent years, scientific attention has been directed to incretin hormones and their role in glycemic control.
Selected Important Risk Information About JANUMET
JANUMET is contraindicated in patients with renal disease or renal dysfunction (serum creatinine levels >1.5 mg/dL in males and >1.4 mg/dL in females) or abnormal creatinine clearance; acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma; or history of a serious hypersensitivity reaction to JANUMET or sitagliptin (one of the components of JANUMET), such as anaphylaxis or angioedema.
Please read the Boxed Warning for JANUMET about lactic acidosis.
Selected Important Risk Information About JANUVIA
When JANUVIA was used in combination with a sulfonylurea or insulin, medications known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo. Therefore, a lower dose of sulfonylurea or insulin may be required to reduce the risk of hypoglycemia.
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